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Professor Jeremy Taylor
Tutor in Physiological Sciences, O'Brien-Abraham Fellow, Associate Professor of Human Anatomy
Director of Pre-Clinical Studies
Pre-clinical medicine Anatomy, Embryology, Histology http://www.mstc.ox.ac.uk/
Pre-clinical medicine Neuroscience http://www.mstc.ox.ac.uk/
Graduate Entry Medicine Embryology and Neuroscience
FHS/MSc lectures/tutorials in neural development and CNS repair
Chairman MSC Neuroscience and 4 Year Wellcome Trust programme in Neuroscience http://www.medsci.ox.ac.uk/neuroscience
Lecturer Brasenose College
College & university roles and committees
- Fellow and Tutor in Medicine
- Governing Body
Department of Physiology Anatomy and Genetics
How do nerve fibres know where to grow and why do they fail to re-grow when the nervous system is damaged? We are interested in the development and regeneration of the vertebrate central nervous system, particularly the visual and corticospinal systems, and specifically at points of axon decussation, which are complex decision regions. In development we are interested in the specification of retinal and cortical neurons to project to specific targets and the development of the known regions where such axons respond to guidance cues in development.
The regeneration of axons within the adult CNS is characteristically very poor, especially for projection neurons. However, we have shown that retinal axons will re-navigate their appropriate pathways and re-establish connectivity during a defined time window of late development. At this time the neurons are still capable of transcribing their original growth related genes, and are in a CNS environment that is neither inhibitory, nor has lost the guidance cues essential for correct navigation. We are currently exploring the limits on this response using both neurotrophins and Glial cell derived factors to extend the regenerative period.
Dallimore EJ, Park KK, Pollett MA, Taylor JSH and Harvey AR. (2010) The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate. Exp Neurol. 225(2):353-65.
Molnár Z and Taylor JSH. (2010). Shining a spotlight on headaches. Nat Neurosci. 13:150-1.
Ma CH, and Taylor JSH. (2010). Trophic responsiveness of purified postnatal and adult rat retinal ganglion cells. Cell Tissue Res.339:297-310.
Ma CH, Bampton ET, Evans MJ, and Taylor JSH. (2010). Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways. Neuroscience. 165:463-74.
Ma CH, Palmer A, and Taylor JSH. (2009). Synergistic effects of osteonectin and NGF in promoting survival and neurite outgrowth of superior cervical ganglion neurons. Brain Res.1289:1-13.
Wang J, Chan CK, Taylor JSH, and Chan SO. (2008). The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm. J Neurosci Res. 86:2581-90.
Wang J, Chan CK, Taylor JSH, and Chan SO. (2008) Localization of Nogo and its receptor in the optic pathway of mouse embryos. J Neurosci Res. 86:1721-33.
de Melo Reis RA, Cabral-da-Silva MC, de Mello FG, and Taylor JSH. (2008). Müller glia factors induce survival and neuritogenesis of peripheral and central neurons. Brain Res. 18: 1205:1-11.
Pembroke's medical students are a hard-working and ambitious group. The course is very demanding, but despite this many are also able to fit sport or other activities into their week.