Dr Holger Kramer

Stipendiary Lecturer

At Pembroke I teach Organic Chemistry to first year students and ‘Metal ions in biology’ to second year biochemists. I have also been involved in postgraduate teaching within the Doctoral Training Centre at the University of Oxford (Introduction to Organic Chemistry) and the OXION Ion Channels initiative at the Department of Physiology, Anatomy and Genetics (Introduction to Proteomics).

I studied Chemistry in Marburg, Germany and at the University of Birmingham graduating with a MSci degree in 2002. This was followed by doctoral studies in Oxford at the Department of Organic Chemistry working on the synthesis of glycoprotein mimics as biological probes. My postdoctoral research with Dr Benedikt Kessler at the Nuffield Department of Medicine introduced me to the use of mass spectrometry and proteomics in the investigation of infectious diseases and post-translational protein modifications. In 2010 I moved to the Department of Physiology, Anatomy and Genetics and to take up responsibility for the operation of the OXION Proteomics facility.

My research interests focus on the application of proteomics and mass spectrometry to the investigation of cellular physiology. In particular I am interested in protein ubiquitination and other regulatory post-translational modifications. This includes detailed characterisation of the enzymes responsible for the attachment of these modifiers to protein surfaces and their subsequent removal. I also have an active interest in the development of novel proteomics methods and mass spectrometry-based assays.